NDLI: Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells

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Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells

Content Provider	MDPI
Author	Hasan, Mahmoud ElKhoury, Kamil Belhaj, Nabila Kahn, Cyril Tamayol, Ali Barberi-Heyob, Muriel Arab-Tehrany, Elmira Linder, Michel
Copyright Year	2020
Description	Current anticancer drugs exhibit limited efficacy and initiate severe side effects. As such, identifying bioactive anticancer agents that can surpass these limitations is a necessity. One such agent, curcumin, is a polyphenolic compound derived from turmeric, and has been widely investigated for its potential anti-inflammatory and anticancer effects over the last 40 years. However, the poor bioavailability of curcumin, caused by its low absorption, limits its clinical use. In order to solve this issue, in this study, curcumin was encapsulated in chitosan-coated nanoliposomes derived from three natural lecithin sources. Liposomal formulations were all in the nanometric scale (around 120 nm) and negatively charged (around −40 mV). Among the three lecithins, salmon lecithin presented the highest growth-inhibitory effect on MCF-7 cells (two times lower growth than the control group for 12 µM of curcumin and four times lower for 20 µM of curcumin). The soya and rapeseed lecithins showed a similar growth-inhibitory effect on the tumor cells. Moreover, coating nanoliposomes with chitosan enabled a higher loading efficiency of curcumin (88% for coated liposomes compared to 65% for the non-coated liposomes) and a stronger growth-inhibitory effect on MCF-7 breast cancer cells.
Starting Page	217
e-ISSN	16603397
DOI	10.3390/md18040217
Journal	Marine drugs
Issue Number	4
Volume Number	18
Language	English
Publisher	MDPI
Publisher Date	2020-04-17
Access Restriction	Open
Subject Keyword	Marine drugs Marine Drugs Pharmacology and Pharmacy Breast Cancer Mcf-7 Liposomes Encapsulation Chitosan Curcumin
Content Type	Text
Resource Type	Article

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