NDLI: Natural Approaches for Neurological Disorders—The Neuroprotective Potential of Codium tomentosum

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Natural Approaches for Neurological Disorders—The Neuroprotective Potential of Codium tomentosum

Content Provider	MDPI
Author	Silva, Joana Martins, Alice Alves, Celso Pinteus, Susete Gaspar, Helena Alfonso, Amparo Pedrosa, Rui
Copyright Year	2020
Description	Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and is characterized by a progressive degeneration of the dopaminergic neurons in the substantianigra. Although not completely understood, several abnormal cellular events are known to be related with PD progression, such as oxidative stress, mitochondrial dysfunction and apoptosis. Accordingly, the aim of this study was to evaluate the neuroprotective effects of Codium tomentosum enriched fractions in a neurotoxicity model mediated by 6-hydroxydopamine (6-OHDA) on SH-SY5Y human cells, and the disclosure of their mechanisms of action. Additionally, a preliminary chemical screening of the most promising bioactive fractions of C. tomentosum was carried out by GC-MS analysis. Among the tested fractions, four samples exhibited the capacity to revert the neurotoxicity induced by 6-OHDA to values higher or similar to the vitamin E (90.11 ± 3.74% of viable cells). The neuroprotective effects were mediated by the mitigation of reactive oxygen species (ROS) generation, mitochondrial dysfunctions and DNA damage, together with the reduction of Caspase-3 activity. Compounds belonging to different chemical classes, such as terpenes, alcohols, carboxylic acids, aldehydes, esters, ketones, saturated and unsaturated hydrocarbons were tentatively identified by GC-MS. The results show that C. tomentosum is a relevant source of neuroprotective agents, with particular interest for preventive therapeutics.
Starting Page	5478
e-ISSN	14203049
DOI	10.3390/molecules25225478
Journal	Molecules
Issue Number	22
Volume Number	25
Language	English
Publisher	MDPI
Publisher Date	2020-11-23
Access Restriction	Open
Subject Keyword	Molecules Integrative and Complementary Medicine Seaweed Marine Natural Products Neurodegenerative Disease Sh-sy5y Cells Oxidative Stress Mitochondrial Dysfunction
Content Type	Text
Resource Type	Article

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