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The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment
| Content Provider | MDPI |
|---|---|
| Author | Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Mikhaleva, Liudmila M. Orekhov, Alexander N. |
| Copyright Year | 2021 |
| Description | Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria—primarily, the regulation of mitochondria-mediated apoptosis, $Ca^{2+}$ homeostasis, dynamics, energy production, and associated reactive oxygen species generation. Recent studies have successfully confirmed the mitochondrial aetiology of thyroid carcinogenesis. In this review, we focus on the recent progress in understanding the molecular mechanisms of thyroid cancer relating to altered mitochondrial metabolism. We also discuss the repurposing of known drugs and the induction of mitochondria-mediated apoptosis as a new trend in the development of anti-TC therapy. |
| Starting Page | 460 |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms23010460 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-31 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Molecular Sciences Urology and Nephrology Thyroid Cancer Mitophagy Mitochondrial Dna Mutation Mitochondrial Dynamics Apoptosis |
| Content Type | Text |
| Resource Type | Article |
