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Prevalence of Clostridioides difficile Infection in Critically Ill Patients with Extreme Leukocytosis and Diarrhea
| Content Provider | MDPI |
|---|---|
| Author | O’Gara, Brian Teja, Bijan Alibhai, Nafeesa Rubenfeld, Gordon Taggart, Linda Jivraj, Naheed Hirji, Sameer Shaefi, Shahzad |
| Copyright Year | 2021 |
| Description | While early empiric antibiotic therapy is beneficial for patients presenting with sepsis, the presentation of sepsis from Clostridioides difficile (formerly Clostridium difficile) infection (CDI) has not been well studied in large cohorts. We sought to determine whether the combination of extreme leukocytosis and diarrhea was strongly predictive of CDI in a cohort of 8659 patients admitted to the intensive care unit. We found that CDI was present in 15.0% (95% CI, 12.1–18.3%) of patients with extreme leukocytosis and diarrhea and that mortality for those with CDI, diarrhea, and extreme leukocytosis was 33.8% (95% CI, 23.2–44.3%). These data support consideration of empiric treatment for CDI in unstable critically ill patients with extreme leukocytosis and diarrhea, along with treatment of other possible sources of sepsis as appropriate. Empiric treatment for CDI can usually be discontinued promptly, along with narrowing of other broad-spectrum antimicrobial coverage, if a sensitive C. difficile test is negative. |
| Ending Page | 22 |
| Page Count | 5 |
| Starting Page | 18 |
| e-ISSN | 20367449 |
| DOI | 10.3390/idr13010003 |
| Journal | Infectious Disease reports |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-01 |
| Access Restriction | Open |
| Subject Keyword | Infectious Disease reports Infectious Disease Reports Infectious Diseases Clostridium Difficile Clostridioides Difficile Leukocytosis Sepsis Critical Care Medicine |
| Content Type | Text |
| Resource Type | Article |
