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Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
| Content Provider | MDPI |
|---|---|
| Author | Milazzo, Giorgio Mercatelli, Daniele Muzio, Giulia Di Triboli, Luca Rosa, Piergiuseppe De Perini, Giovanni Giorgi, Federico M. |
| Copyright Year | 2020 |
| Description | Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes. |
| Starting Page | 556 |
| e-ISSN | 20734425 |
| DOI | 10.3390/genes11050556 |
| Journal | Genes |
| Issue Number | 5 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-05-15 |
| Access Restriction | Open |
| Subject Keyword | Genes Medicinal Chemistry Histone Deacetylases Hdac Chromatin Epigenetics Epigenomics Hdac Inhibitors Hdaci Gene Networks Cancer Phylogenesis |
| Content Type | Text |
| Resource Type | Article |
