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Cost-Effectiveness of Digital Breast Tomosynthesis vs. Abbreviated Breast MRI for Screening Women with Intermediate Risk of Breast Cancer—How Low-Cost Must MRI Be?
| Content Provider | MDPI |
|---|---|
| Author | Johannes, Rübenthaler Tollens, Fabian Baltzer, Pascal Dietzel, Matthias Froelich, Matthias Kaiser, Clemens |
| Copyright Year | 2021 |
| Description | Background: Digital breast tomosynthesis (DBT) and abbreviated breast MRI (AB-MRI) offer superior diagnostic performance compared to conventional mammography in screening women with intermediate risk of breast cancer due to dense breast tissue. The aim of this model-based economic evaluation was to analyze whether AB-MRI is cost-effective in this cohort compared to DBT. Methods: Decision analysis and Markov simulations were used to model the cumulative costs and quality-adjusted life-years (QALYs) over a time horizon of 30 years. Model input parameters were adopted from recent literature. Deterministic and probabilistic sensitivity analyses were applied to test the stability of the model. Results: In the base-case scenario, the costs of an AB-MRI examination were defined to equal the costs of a full protocol acquisition. Two-yearly screening of women with dense breasts resulted in cumulative discounted costs of $8798 and $9505 for DBT and AB-MRI, and cumulative discounted effects of 19.23 and 19.27 QALYs, respectively, with an incremental cost-effectiveness ratio of $20,807 per QALY gained in the base-case scenario. By reducing the cost of an AB-MRI examination below a threshold of $241 in sensitivity analyses, AB-MRI would become cost-saving compared to DBT. Conclusion: In comparison to DBT, AB-MRI can be considered cost-effective up to a price per examination of $593 in screening patients at intermediate risk of breast cancer. |
| Starting Page | 1241 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13061241 |
| Journal | Cancers |
| Issue Number | 6 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-12 |
| Access Restriction | Open |
| Subject Keyword | Cancers Womens Studies Tomosynthesis Ab-mri Mr-mammography Breast Cancer Intermediate-risk Screening Cost-effectiveness Analyses Cost-effectiveness Threshold |
| Content Type | Text |
| Resource Type | Article |
