NDLI: Novel Targeted Therapeutic Strategies for Ewing Sarcoma

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Novel Targeted Therapeutic Strategies for Ewing Sarcoma

Content Provider	MDPI
Author	Fayzullina, Daria Tsibulnikov, Sergey Stempen, Mikhail Schroeder, Brett A. Kumar, Naveen Kharwar, Rajesh Kumar Acharya, Arbind Timashev, Peter Ulasov, Ilya
Copyright Year	2022
Description	Ewing sarcoma (ES) is an uncommon cancer that arises in mesenchymal tissues and represents the second most widespread malignant bone neoplasm after osteosarcoma in children. Amplifications in genomic, proteomic, and metabolism are characteristics of sarcoma, and targeting altered cancer cell molecular processes has been proposed as the latest promising strategy to fight cancer. Recent technological advancements have elucidated some of the underlying oncogenic characteristics of Ewing sarcoma. Offering new insights into the physiological basis for this phenomenon, our current review examines the dynamics of ES signaling as it related to both ES and the microenvironment by integrating genomic and proteomic analyses. An extensive survey of the literature was performed to compile the findings. We have also highlighted recent and ongoing studies integrating metabolomics and genomics aimed at better understanding the complex interactions as to how ES adapts to changing biochemical changes within the tumor microenvironment.
Starting Page	1988
e-ISSN	20726694
DOI	10.3390/cancers14081988
Journal	Cancers
Issue Number	8
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2022-04-14
Access Restriction	Open
Subject Keyword	Cancers Ewing Sarcoma Progression Targeted Therapy Ewsr1/fli1
Content Type	Text
Resource Type	Article

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