NDLI: Collagen Peptides Derived from Sipunculus nudus Accelerate Wound Healing

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Collagen Peptides Derived from Sipunculus nudus Accelerate Wound Healing

Content Provider	MDPI
Author	Lin, Haisheng Zheng, Zhihong Yuan, Jianjun Zhang, Chaohua Cao, Wenhong Qin, Xiao Ming
Copyright Year	2021
Description	Marine collagen peptides have high potential in promoting skin wound healing. This study aimed to investigate wound healing activity of collagen peptides derived from Sipunculus nudus (SNCP). The effects of SNCP on promoting healing were studied through a whole cortex wound model in mice. Results showed that SNCP consisted of peptides with a molecular weight less than 5 kDa accounted for 81.95%, rich in Gly and Arg. SNCP possessed outstanding capacity to induce human umbilical vein endothelial cells (HUVEC), human immortalized keratinocytes (HaCaT) and human skin fibroblasts (HSF) cells proliferation and migration in vitro. In vivo, SNCP could markedly improve the healing rate and shorten the scab removal time, possessing a scar-free healing effect. Compared with the negative control group, the expression level of tumor necrosis factor-α, interleukin-1β and transforming growth factor-β1 (TGF-β1) in the SNCP group was significantly down-regulated at 7 days post-wounding (p < 0.01). Moreover, the mRNA level of mothers against decapentaplegic homolog 7 (Smad7) in SNCP group was up-regulated (p < 0.01); in contrast, type II TGF-β receptors, collagen I and α-smooth muscle actin were significantly down-regulated at 28 days (p < 0.01). These results indicate that SNCP possessed excellent activity of accelerating wound healing and inhibiting scar formation, and its mechanism was closely related to reducing inflammation, improving collagen deposition and recombination and blockade of the TGF-β/Smads signal pathway. Therefore, SNCP may have promising clinical applications in skin wound repair and scar inhibition.
Starting Page	1385
e-ISSN	14203049
DOI	10.3390/molecules26051385
Journal	Molecules
Issue Number	5
Volume Number	26
Language	English
Publisher	MDPI
Publisher Date	2021-03-04
Access Restriction	Open
Subject Keyword	Molecules Integrative and Complementary Medicine Sipunculus Nudus Collagen Peptides Wound Healing Inflammation Scar Inhibition Collagen Transforming Growth Factor
Content Type	Text
Resource Type	Article

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