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Spatially and Temporally Resolved Ambient $PM_{2.5}$ in Relation to Preterm Birth
| Content Provider | MDPI |
|---|---|
| Author | Cowell, Whitney Colicino, Elena Zhang, Xueying Ledyard, Rachel Burris, Heather H. Hacker, Michele R. Kloog, Itai Just, Allan Wright, Robert O. Wright, Rosalind J. |
| Copyright Year | 2021 |
| Description | Growing evidence suggests that maternal exposure to ambient fine particulate matter $(PM_{2.5}$) during pregnancy is associated with preterm birth; however, few studies have examined critical windows of exposure, which can help elucidate underlying biologic mechanisms and inform public health messaging for limiting exposure. Participants included 891 mother–newborn pairs enrolled in a U.S.-based pregnancy cohort study. Daily residential $PM_{2.5}$ concentrations at a 1 × 1 $km^{2}$ resolution were estimated using a satellite-based hybrid model. Gestational age at birth was abstracted from electronic medical records and preterm birth (PTB) was defined as <37 completed weeks of gestation. We used Critical Window Variable Selection to examine weekly $PM_{2.5}$ exposure in relation to the odds of PTB and examined sex-specific associations using stratified models. The mean ± standard deviation $PM_{2.5}$ level averaged across pregnancy was 8.13 ± 1.10 $µg/m^{3}$. $PM_{2.5}$ exposure was not associated with an increased odds of PTB during any gestational week. In sex-stratified models, we observed a marginal increase in the odds of PTB with exposure occurring during gestational week 16 among female infants only. This study does not provide strong evidence supporting an association between weekly exposure to $PM_{2.5}$ and preterm birth. |
| Starting Page | 352 |
| e-ISSN | 23056304 |
| DOI | 10.3390/toxics9120352 |
| Journal | Toxics |
| Issue Number | 12 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-14 |
| Access Restriction | Open |
| Subject Keyword | Toxics Pediatrics and Child Health Fine Particulate Matter Pm2.5 Pregnancy Prenatal Preterm Birth Fetal Sex Air Pollution |
| Content Type | Text |
| Resource Type | Article |
