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Patient and Physician Preferences for Regimen Attributes for the Treatment of HIV in the United States and Canada
| Content Provider | MDPI |
|---|---|
| Author | Bertrand, Lebouché Gelhorn, Heather Garris, Cindy Arthurs, Erin Spinelli, Frank Cutts, Katelyn Chua, Gin Nie Collacott, Hannah Lowman, Erik Rice, Howard Heidenreich, Sebastian |
| Copyright Year | 2022 |
| Description | A long-acting injectable (LAI) antiretroviral therapy (ART) regimen is now available as a treatment option for virologically suppressed adults with HIV-1. This study assessed preference for a LAI regimen using an online survey of virally suppressed people living with HIV (PLWH) and physicians treating HIV in the US and Canada. Preference was elicited in a discrete choice experiment (DCE) with three choice options (switch to a LAI regimen, switch to another daily oral ART regimen, or stay on their current daily oral ART regimen) and four treatment attributes. A total of 553 PLWH and 450 physicians completed the survey. From the DCE results, 59% of PLWH were predicted to prefer a LAI over an alternative oral ART or staying on their current oral treatment, and 55–66% of physicians were predicted to recommend LAI for PLWH, depending on the treatment challenge scenario presented. PLWH indicated LAI would remove daily reminders of HIV (75%) and reduce feelings of being stigmatized (68%). A majority of PLWH and physicians preferred a LAI over oral ART to overcome treatment challenges such as daily pill burden and adherence. These benefits of LAI ART along with preferences of PLWH and physicians can help to inform ART choice. |
| Starting Page | 334 |
| e-ISSN | 20754426 |
| DOI | 10.3390/jpm12030334 |
| Journal | Journal of Personalized Medicine |
| Issue Number | 3 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-02-23 |
| Access Restriction | Open |
| Subject Keyword | Journal of Personalized Medicine Biomedical Social Sciences Antiretroviral Therapy Discrete Choice Experiment (dce) Hiv Long-acting Injectable (lai) Patient Preference Physician Preference |
| Content Type | Text |
| Resource Type | Article |
