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Mitochondrial Dysfunction in Diseases, Longevity, and Treatment Resistance: Tuning Mitochondria Function as a Therapeutic Strategy
| Content Provider | MDPI |
|---|---|
| Author | Tomita, Kazuo Kuwahara, Yoshikazu Igarashi, Kento Roudkenar, Mehryar Habibi Roushandeh, Amaneh Mohammadi Kurimasa, Akihiro Sato, Tomoaki |
| Copyright Year | 2021 |
| Description | Mitochondria are very important intracellular organelles because they have various functions. They produce ATP, are involved in cell signaling and cell death, and are a major source of reactive oxygen species (ROS). Mitochondria have their own DNA (mtDNA) and mutation of mtDNA or change the mtDNA copy numbers leads to disease, cancer chemo/radioresistance and aging including longevity. In this review, we discuss the mtDNA mutation, mitochondrial disease, longevity, and importance of mitochondrial dysfunction in cancer first. In the later part, we particularly focus on the role in cancer resistance and the mitochondrial condition such as mtDNA copy number, mitochondrial membrane potential, ROS levels, and ATP production. We suggest a therapeutic strategy employing mitochondrial transplantation (mtTP) for treatment-resistant cancer. |
| Starting Page | 1348 |
| e-ISSN | 20734425 |
| DOI | 10.3390/genes12091348 |
| Journal | Genes |
| Issue Number | 9 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-08-29 |
| Access Restriction | Open |
| Subject Keyword | Genes Oncology Mitochondria Mitochondrial Dna Clinically Relevant Radioresistant (crr) Cells Cancer Radioresistance |
| Content Type | Text |
| Resource Type | Article |
