NDLI: Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro

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Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro

Content Provider	MDPI
Author	Inden, Masatoshi Takagi, Ayaka Kitai, Hazuki Ito, Taisei Kurita, Hisaka Honda, Ryo Kamatari, Yuji O. Nozaki, Sora Wen, Xiaopeng Hijioka, Masanori Kitamura, Yoshihisa Hozumi, Isao
Copyright Year	2021
Description	Aggregation of α-synuclein (α-Syn) is implicated in the pathogenesis of Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Therefore, the removal of α-Syn aggregation could lead to the development of many new therapeutic agents for neurodegenerative diseases. In the present study, we s쳮ded in generating a new α-Syn stably expressing cell line using a piggyBac transposon system to investigate the neuroprotective effect of the flavonoid kaempferol on α-Syn toxicity. We found that kaempferol provided significant protection against α-Syn-related neurotoxicity. Furthermore, kaempferol induced autophagy through an increase in the biogenesis of lysosomes by inducing the expression of transcription factor EB and reducing the accumulation of α-Syn; thus, kaempferol prevented neuronal cell death. Moreover, kaempferol directly blocked the amyloid fibril formation of α-Syn. These results support the therapeutic potential of kaempferol in diseases such as synucleinopathies that are characterized by α-Syn aggregates.
Starting Page	11484
e-ISSN	14220067
DOI	10.3390/ijms222111484
Journal	International Journal of Molecular Sciences
Issue Number	21
Volume Number	22
Language	English
Publisher	MDPI
Publisher Date	2021-10-25
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Neurosciences Α-synuclein Synucleinopathies Kaempferol Parkinson's Disease Dementia with Lewy Bodies Multiple System Atrophy Autophagy
Content Type	Text
Resource Type	Article

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