NDLI: Cell-Secreted Vesicles: Novel Opportunities in Cancer Diagnosis, Monitoring and Treatment

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Cell-Secreted Vesicles: Novel Opportunities in Cancer Diagnosis, Monitoring and Treatment

Content Provider	MDPI
Author	Catoni, Cristina Paolo, Veronica Di Rossi, Elisabetta Quintieri, Luigi Zamarchi, Rita
Copyright Year	2021
Description	Extracellular vesicles (EVs) are important mediators of intercellular communication playing a pivotal role in the regulation of physiological and pathological processes, including cancer. In particular, there is significant evidence suggesting that tumor-derived EVs exert an immunosuppressive activity during cancer progression, as well as stimulate tumor cell migration, angiogenesis, invasion and metastasis. The use of EVs as a liquid biopsy is currently a fast-growing area of research in medicine, with the potential to provide a step-change in the diagnosis and treatment of cancer, allowing the prediction of both therapy response and prognosis. EVs could be useful not only as biomarkers but also as drug delivery systems, and may represent a target for anticancer therapy. In this review, we attempted to summarize the current knowledge about the techniques used for the isolation of EVs and their roles in cancer biology, as liquid biopsy biomarkers and as therapeutic tools and targets.
Starting Page	1118
e-ISSN	20754418
DOI	10.3390/diagnostics11061118
Journal	Diagnostics
Issue Number	6
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2021-06-19
Access Restriction	Open
Subject Keyword	Diagnostics Biomedical Engineering Extracellular Vesicles Cancer Biology Liquid Biopsy Therapeutic Tools
Content Type	Text
Resource Type	Article

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