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Mediterranean Diet and White Blood Cell Count—A Randomized Controlled Trial
| Content Provider | MDPI |
|---|---|
| Author | Olga, Castañer Xavier, Pintó Miguel, Martínez-González Jordi, Salas-Salvadó Ángel Alonso-Gómez, Enrique, Gómez-Gracia Ana, García-Arellano Jos, é Sorlí Andr, és Díaz-López Montserrat, Cofán Hernáez, Álvaro Lassale, Camille Castro-Barquero, Sara Babio, Nancy Ros, Emilio Tresserra-Rimbau, Anna Corella, Dolores Lapetra, José Fiol, Miquel Serra-Majem, Lluis Sacanella, Emilio Estruch, Ramón |
| Copyright Year | 2021 |
| Description | We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × $10^{9}$ leukocytes/L), mild leukopenia (<4.5 × $10^{9}$ leukocytes/L), or severe leukopenia (<3.5 × $10^{9}$ leukocytes/L) in individuals without the condition at baseline (n = 3190, n = 2925, and n = 3190, respectively). We also examined whether MedDiet modified the association between leukocyte count alterations and all-cause mortality. Both MedDiet interventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06% in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54 [0.36–0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groups combined; hazard ratio: 0.25 [0.10–0.60]). High cumulative adherence to a MedDiet was linked to lower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; $HR_{Q4-Q1}$: 0.29 [0.085–0.99]) and attenuated the association between leukopenia and all-cause mortality (P-interaction = 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations in high cardiovascular risk individuals. |
| Starting Page | 1268 |
| e-ISSN | 23048158 |
| DOI | 10.3390/foods10061268 |
| Journal | Foods |
| Issue Number | 6 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-02 |
| Access Restriction | Open |
| Subject Keyword | Foods Endocrinology and Metabolism White Blood Cell Count Mediterranean Diet Leukopenia Leukocytosis Randomized Controlled Trial Prevention |
| Content Type | Text |
| Resource Type | Article |
