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Glucagon-Like Peptide-1 Receptor Agonists for Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: An Updated Meta-Analysis of Randomized Controlled Trials
| Content Provider | MDPI |
|---|---|
| Author | Mantovani, Alessandro Petracca, Graziana Beatrice, Giorgia Csermely, Alessandro Lonardo, Amedeo Targher, Giovanni |
| Copyright Year | 2021 |
| Description | To assess the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for treatment of nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH), we performed a systematic review and meta-analysis of randomized controlled trials (RCTs). Three large electronic databases were systematically searched (up to 15 December 2020) to identify placebo-controlled or active-controlled RCTs using different GLP-1 RAs. We included eleven placebo-controlled or active-controlled phase-2 RCTs (involving a total of 936 middle-aged individuals) that used liraglutide (n = 6 RCTs), exenatide (n = 3 RCTs), dulaglutide (n = 1 RCT) or semaglutide (n = 1 RCT) to specifically treat NAFLD or NASH, detected by liver biopsy (n = 2 RCTs) or imaging techniques (n = 9 RCTs). Compared to placebo or reference therapy, treatment with GLP-1 RAs for a median of 26 weeks was associated with significant reductions in the absolute percentage of liver fat content on magnetic resonance-based techniques (pooled weighted mean difference: −3.92%, 95% confidence intervals (CI) −6.27% to −1.56%) and serum liver enzyme levels, as well as with greater histological resolution of NASH without worsening of liver fibrosis (pooled random-effects odds ratio 4.06, 95% CI 2.52–6.55; for liraglutide and semaglutide only). In conclusion, treatment with GLP-1 RAs (mostly liraglutide and semaglutide) is a promising treatment option for NAFLD or NASH that warrants further investigation. |
| Starting Page | 73 |
| e-ISSN | 22181989 |
| DOI | 10.3390/metabo11020073 |
| Journal | Metabolites |
| Issue Number | 2 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-27 |
| Access Restriction | Open |
| Subject Keyword | Metabolites Gastroenterology and Hepatology Glp-1 Receptor Agonists Exenatide Liraglutide Semaglutide Dulaglutide Nonalcoholic Fatty Liver Disease Nafld Nonalcoholic Steatohepatitis Nash Type 2 Diabetes Mellitus |
| Content Type | Text |
| Resource Type | Article |
