NDLI: The Emerging Role of CT-Based Imaging in Adipose Tissue and Coronary Inflammation

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The Emerging Role of CT-Based Imaging in Adipose Tissue and Coronary Inflammation

Content Provider	MDPI
Author	Yuvaraj, Jeremy Cheng, Kevin Lin, Andrew Psaltis, Peter Nicholls, Stephen Wong, Dennis
Copyright Year	2021
Description	A large body of evidence arising from recent randomized clinical trials demonstrate the association of vascular inflammatory mediators with coronary artery disease (CAD). Vascular inflammation localized in the coronary arteries leads to an increased risk of CAD-related events, and produces unique biological alterations to local cardiac adipose tissue depots. Coronary computed tomography angiography (CTA) provides a means of mapping inflammatory changes to both epicardial adipose tissue (EAT) and pericoronary adipose tissue (PCAT) as independent markers of coronary risk. Radiodensity or attenuation of PCAT on coronary CTA, notably, provides indirect quantification of coronary inflammation and is emerging as a promising non-invasive imaging implement. An increasing number of observational studies have shown robust associations between PCAT attenuation and major coronary events, including acute coronary syndrome, and ‘vulnerable’ atherosclerotic plaque phenotypes that are associated with an increased risk of the said events. This review outlines the biological characteristics of both EAT and PCAT and provides an overview of the current literature on PCAT attenuation as a surrogate marker of coronary inflammation.
Starting Page	1196
e-ISSN	20734409
DOI	10.3390/cells10051196
Journal	Cells
Issue Number	5
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-05-13
Access Restriction	Open
Subject Keyword	Cells Peripheral Vascular Disease Atherosclerosis Coronary Artery Disease Computed Tomography Coronary Angiography Coronary Inflammation Adipose Tissue Epicardial Adipose Tissue Pericoronary Adipose Tissue
Content Type	Text
Resource Type	Article

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