NDLI: Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus-2

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Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus-2

Content Provider	MDPI
Author	Rakib, Ahmed Sami, Saad Islam, Ashiqul Ahmed, Shahriar Faiz, Farhana Khanam, Bibi Marma, Kay Rahman, Maksuda Uddin, Mir Nainu, Firzan Emran, Talha Simal-Gandara, Jesus
Copyright Year	2020
Description	With an increasing fatality rate, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has emerged as a promising threat to human health worldwide. Recently, the World Health Organization (WHO) has announced the infectious disease caused by SARS-CoV-2, which is known as coronavirus disease-2019 (COVID-2019), as a global pandemic. Additionally, the positive cases are still following an upward trend worldwide and as a corollary, there is a need for a potential vaccine to impede the progression of the disease. Lately, it has been documented that the nucleocapsid (N) protein of SARS-CoV-2 is responsible for viral replication and interferes with host immune responses. We comparatively analyzed the sequences of N protein of SARS-CoV-2 for the identification of core attributes and analyzed the ancestry through phylogenetic analysis. Subsequently, we predicted the most immunogenic epitope for the T-cell and B-cell. Importantly, our investigation mainly focused on major histocompatibility complex (MHC) class I potential peptides and NTASWFTAL interacted with most human leukocyte antigen (HLA) that are encoded by MHC class I molecules. Further, molecular docking analysis unveiled that NTASWFTAL possessed a greater affinity towards HLA and also available in a greater range of the population. Our study provides a consolidated base for vaccine design and we hope that this computational analysis will pave the way for designing novel vaccine candidates.
Starting Page	5088
e-ISSN	14203049
DOI	10.3390/molecules25215088
Journal	Molecules
Issue Number	21
Volume Number	25
Language	English
Publisher	MDPI
Publisher Date	2020-11-02
Access Restriction	Open
Subject Keyword	Molecules Mathematical and Computational Biology Covid-19 Sars-cov-2 Vaccine Nucleocapsid Protein Bioinformatics Immunoinformatics Epitope
Content Type	Text
Resource Type	Article

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