NDLI: Five-Year Outcome of Aflibercept Monotherapy for Exudative Age-Related Macular Degeneration with Good Baseline Visual Acuity

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Five-Year Outcome of Aflibercept Monotherapy for Exudative Age-Related Macular Degeneration with Good Baseline Visual Acuity

Content Provider	MDPI
Author	Kikushima, Wataru Sakurada, Yoichi Sugiyama, Atsushi Yoneyama, Seigo Matsubara, Mio Fukuda, Yoshiko Kashiwagi, Kenji
Copyright Year	2021
Description	We investigated the long-term visual and anatomical outcomes of aflibercept monotherapy for exudative age-related macular degeneration (AMD) with good baseline best-corrected visual acuity (BCVA). A medical chart review was performed for 40 consecutive patients with baseline decimal BCVA ≥ 0.6 secondary to exudative AMD. Three monthly injections were administrated, and thereafter additional injection was performed if needed over 5 years. In total, 13 eyes with neovascular AMD (nAMD) and 27 eyes with polypoidal choroidal vasculopathy (PCV) were enrolled. In both groups, the mean BCVA significantly improved at the 12-month visit (p < 0.05). However, the significant improvement in BCVA disappeared at the 24-month visit, and the final mean BCVA was equivalent to that at baseline (p = 0.17 in the nAMD group and p = 0.15 in the PCV group). The median number of injections required after the loading dose was 15.0 during the 5-year follow-up (nAMD:15.0 vs. PCV:15). During the study period, 37 (92.5%) eyes required retreatment(s). Cox regression analysis demonstrated that the protective allele of ARMS2 A69S was associated with a retreatment-free period from the initial injection (p = 0.041, repeated forward selection method). As-needed aflibercept monotherapy is a preferable treatment option for exudative AMD with good initial visual acuity regardless of nAMD or PCV during the 5-year study period.
Starting Page	1098
e-ISSN	20770383
DOI	10.3390/jcm10051098
Journal	Journal of clinical medicine
Issue Number	5
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-03-05
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Ophthalmology Aflibercept Monotherapy Polypoidal Choroidal Vasculopathy Neovascular Age-related Macular Degeneration Good Baseline Visual Acuity
Content Type	Text
Resource Type	Article

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