NDLI: Moonlighting Proteins Shine New Light on Molecular Signaling Niches

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Moonlighting Proteins Shine New Light on Molecular Signaling Niches

Content Provider	MDPI
Author	Turek, Ilona Irving, Helen
Copyright Year	2021
Description	Plants as sessile organisms face daily environmental challenges and have developed highly nuanced signaling systems to enable suitable growth, development, defense, or stalling responses. Moonlighting proteins have multiple tasks and contribute to cellular signaling cascades where they produce additional variables adding to the complexity or fuzziness of biological systems. Here we examine roles of moonlighting kinases that also generate 3’,5’-cyclic guanosine monophosphate (cGMP) in plants. These proteins include receptor like kinases and lipid kinases. Their guanylate cyclase activity potentiates the development of localized cGMP-enriched nanodomains or niches surrounding the kinase and its interactome. These nanodomains contribute to allosteric regulation of kinase and other molecules in the immediate complex directly or indirectly modulating signal cascades. Effects include downregulation of kinase activity, modulation of other members of the protein complexes such as cyclic nucleotide gated channels and potential triggering of cGMP-dependent degradation cascades terminating signaling. The additional layers of information provided by the moonlighting kinases are discussed in terms of how they may be used to provide a layer of fuzziness to effectively modulate cellular signaling cascades.
Starting Page	1367
e-ISSN	14220067
DOI	10.3390/ijms22031367
Journal	International Journal of Molecular Sciences
Issue Number	3
Volume Number	22
Language	English
Publisher	MDPI
Publisher Date	2021-01-29
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Plant Sciences Guanylate Cyclase Receptor Like Kinase Brassinosteroid Insensitive 1 (bri1) Phytosulfokine Receptor 1 (pskr1) Danger Associated Peptide Receptor (pepr1 and Pepr2) Wall Associated Kinase Like 10 (wakl10) Nanodomains Moonlighting Proteins Cryptic Enzyme 3′,5′-cyclic Guanosine Monophosphate (cgmp)
Content Type	Text
Resource Type	Article

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