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Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19
| Content Provider | MDPI |
|---|---|
| Author | Patricia, Peñacoba Sandra, Elizabet Orozco Echevarría Laura, Martínez-Martínez Ivan, Castellví Juárez, Cándido Alserawan, Leticia Castillo, Diego Ortiz, Esther Naranjo, Esther Moga Domingo, Pere Mariscal, Anaís |
| Copyright Year | 2021 |
| Description | It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) is upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels of GDF-15 and correlated them with clinical and laboratory parameters reflecting severity in 84 patients with COVID-19, finding that GDF-15 levels were higher in both patients than in 20 healthy controls and were higher in patients with poorer respiratory function. GDF-15 levels also correlated with interleukin-6, C-reactive protein, ferritin and D-dimer levels and with neutrophilia and lymphopenia. Of all the analysed biomarkers, GDF-15 showed the best area under the receiver operating characteristics curve in identifying patients with poor respiratory function. In conclusion, our data support GDF-15 as a biomarker associated with pulmonary impairment in COVID-19 and so can potentially be useful in stratifying COVID-19 cases by severity. |
| Starting Page | 1998 |
| e-ISSN | 20754418 |
| DOI | 10.3390/diagnostics11111998 |
| Journal | Diagnostics |
| Issue Number | 11 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-10-27 |
| Access Restriction | Open |
| Subject Keyword | Diagnostics Gdf-15 Covid-19 Respiratory Function Inflammation Biomarker |
| Content Type | Text |
| Resource Type | Article |
