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N-Iodosuccinimide as a Precatalyst for Direct Cross-Coupling of Alcohols with C-Nucleophiles under Solvent-Free Reaction Conditions
| Content Provider | MDPI |
|---|---|
| Author | Ajvazi, Njomza Stavber, Stojan |
| Copyright Year | 2020 |
| Description | C–C bond formation is one of the most important implements in synthetic organic chemistry. In pursuit of effective synthetic routes functioning under greener pathways to achieve direct C–C bond formation, we report N-iodosuccinimide (NIS) as the most effective precatalyst among the N-halosuccinimides (NXSs) for the direct cross-coupling of benzyl alcohols with C-nucleophiles under solvent-free reaction conditions (SFRC). The protocol is metal-free, and air- and water-tolerant, providing a large-scale synthesis with almost quantitative yields. |
| Starting Page | 850 |
| e-ISSN | 20734344 |
| DOI | 10.3390/catal10080850 |
| Journal | Catalysts |
| Issue Number | 8 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-08-01 |
| Access Restriction | Open |
| Subject Keyword | Catalysts Organic Chemistry Alcohols N-iodosuccinimide C–c Coupling Solvent-free Reactions Green Chemistry |
| Content Type | Text |
| Resource Type | Article |
