| Content Provider | MDPI |
|---|---|
| Author | Klotz, Alexander Reinhold, Edgar Doello, Sofía Forchhammer, Karl |
| Abstract | Nitrogen starvation acclimation in non-diazotrophic cyanobacteria is characterized by a process termed chlorosis, where the light harvesting pigments are degraded and the cells gradually tune down photosynthetic and metabolic activities. The chlorosis response is governed by a complex and poorly understood regulatory network, which converges at the expression of the nblA gene, the triggering factor for phycobiliprotein degradation. This study established a method that allows uncoupling metabolic and redox-signals involved in nitrogen-starvation acclimation. Inhibition of glutamine synthetase (GS) by a precise dosage of l-methionine-sulfoximine (MSX) mimics the metabolic situation of nitrogen starvation. Addition of nitrate to such MSX-inhibited cells eliminates the associated redox-stress by enabling electron flow towards nitrate/nitrite reduction and thereby, prevents the induction of nblA expression and the associated chlorosis response. This study demonstrates that nitrogen starvation is perceived not only through metabolic signals, but requires a redox signal indicating over-reduction of PSI-reduced electron acceptors. It further establishes a cryptic role of nitrate/nitrite reductases as electron sinks to balance conditions of over-reduction. |
| File Size | 935936 |
| Ending Page | 904 |
| Page Count | 17 |
| Starting Page | 888 |
| File Format | |
| e-ISSN | 20751729 |
| DOI | 10.3390/life5010888 |
| Journal | Life |
| Issue Number | 1 |
| Volume Number | 5 |
| Language | English |
| Publisher Date | 2015-03-13 |
| Access Restriction | Open |
| Subject Keyword | Synechococcus elongatus PCC 7942 nblA glnB NtcA nitrogen starvation response l-methionine-sulfoximine glutamine synthetase |
| Content Type | Text |
| Resource Type | Article |
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