NDLI: The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study

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The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study

Content Provider	MDPI
Author	Luglio, Harry Sulistyoningrum, Dian Huriyati, Emy Lee, Yi Wan Muda, Wan
Abstract	Background: Obesity has been associated with leptin resistance and this might be caused by genetic factors. The aim of this study was to investigate the gene-lifestyle interaction between −866G/A UCP2 (uncoupling protein 2) gene polymorphism, dietary intake and leptin in a population based study. Methods: This is a cross sectional study conducted in adults living at urban area of Yogyakarta, Indonesia. Data of adiposity, lifestyle, triglyceride, high density lipoprotein (HDL) cholesterol, leptin and UCP2 gene polymorphism were obtained in 380 men and female adults. Results: UCP2 gene polymorphism was not significantly associated with adiposity, leptin, triglyceride, HDL cholesterol, dietary intake and physical activity (all p > 0.05). Leptin was lower in overweight subjects with AA + GA genotypes than those with GG genotype counterparts (p = 0.029). In subjects with AA + GA genotypes there was a negative correlation between leptin concentration (r = −0.324; p < 0.0001) and total energy intake and this correlation was not seen in GG genotype (r = −0.111; p = 0.188). Conclusions: In summary, we showed how genetic variation in −866G/A UCP2 affected individual response to leptin production. AA + GA genotype had a better leptin sensitivity shown by its response in dietary intake and body mass index (BMI) and this explained the protective effect of A allele to obesity.
File Size	358400
File Format	PDF
e-ISSN	20726643
DOI	10.3390/nu9070716
Journal	Nutrients
Issue Number	7
Volume Number	9
Language	English
Publisher Date	2017-07-07
Access Restriction	Open
Subject Keyword	UCP2 leptin dietary intake adiposity obesity
Content Type	Text
Resource Type	Article

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