NDLI: Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

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Volume: 10

Volume: 9

How Flaviviruses Activate and Suppress the Interferon Response

Restriction of Rift Valley Fever Virus Virulence in Mosquito Cells

The Evolution of HIV-1 Diversity in Rural Cameroon and its Implications in Vaccine Design and Trials

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

Surface Transmission or Polarized Egress? Lessons Learned from HTLV Cell-to-Cell Transmission

CCR5: From Natural Resistance to a New Anti-HIV Strategy

A Host of Factors Regulating Influenza Virus Replication

Cross-Reactive Human IgM-Derived Monoclonal Antibodies that Bind to HIV-1 Envelope Glycoproteins

Developing Vaccines to Combat Pandemic Influenza

HIV Genetic Diversity and Drug Resistance

Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials

PEGylated Adenoviruses: From Mice to Monkeys

Lentiviral Vectors and Cystic Fibrosis Gene Therapy

RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis

The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance

Development of Viral Vectors for Use in Cardiovascular Gene Therapy

Issue: 1

Volume: 1

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

Content Provider	MDPI
Author	Singh, Kamalendra Marchand, Bruno Kirby, Karen A. Michailidis, Eleftherios Sarafianos, Stefan G.
Abstract	HIV-1 Reverse Transcriptase (HIV-1 RT) has been the target of numerous approved anti-AIDS drugs that are key components of Highly Active Anti-Retroviral Therapies (HAART). It remains the target of extensive structural studies that continue unabated for almost twenty years. The crystal structures of wild-type or drug-resistant mutant HIV RTs in the unliganded form or in complex with substrates and/or drugs have offered valuable glimpses into the enzyme’s folding and its interactions with DNA and dNTP substrates, as well as with nucleos(t)ide reverse transcriptase inhibitor (NRTI) and non-nucleoside reverse transcriptase inhibitor (NNRTIs) drugs. These studies have been used to interpret a large body of biochemical results and have paved the way for innovative biochemical experiments designed to elucidate the mechanisms of catalysis and drug inhibition of polymerase and RNase H functions of RT. In turn, the combined use of structural biology and biochemical approaches has led to the discovery of novel mechanisms of drug resistance and has contributed to the design of new drugs with improved potency and ability to suppress multi-drug resistant strains.
File Size	2615296
Ending Page	638
Page Count	33
Starting Page	606
File Format	PDF
e-ISSN	19994915
DOI	10.3390/v2020606
Journal	Viruses
Issue Number	2
Volume Number	2
Language	English
Publisher Date	2010-02-11
Access Restriction	Open
Subject Keyword	HIV-1 reverse transcriptase nucleoside RT inhibitors non-nucleoside RT inhibitors translocation defective RT inhibitors drug resistance excision
Content Type	Text
Resource Type	Article

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Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors

APOBEC3 selects V179I in HIV-1 reverse transcriptase to provide selective advantage for non-nucleoside reverse transcriptase inhibitor-resistant mutants

HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors

Mechanisms of HIV-1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors

Mutations in the Reverse Transcriptase and Protease Genes of Human Immunodeficiency Virus-1 from Antiretroviral Naïve and Treated Pediatric Patients

Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase

Selection of Resistance-Conferring Mutations in HIV-1 by the Nucleoside Reverse Transcriptase Inhibitors (+/-)dOTC and (+/-)dOTFC

Impact of Y181C and/or H221Y mutation patterns of HIV-1 reverse transcriptase on phenotypic resistance to available non-nucleoside and nucleoside inhibitors in China

Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

Similar Documents

Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors

APOBEC3 selects V179I in HIV-1 reverse transcriptase to provide selective advantage for non-nucleoside reverse transcriptase inhibitor-resistant mutants

HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors

Mechanisms of HIV-1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors

Mutations in the Reverse Transcriptase and Protease Genes of Human Immunodeficiency Virus-1 from Antiretroviral Naïve and Treated Pediatric Patients

Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase

Selection of Resistance-Conferring Mutations in HIV-1 by the Nucleoside Reverse Transcriptase Inhibitors (+/-)dOTC and (+/-)dOTFC

Impact of Y181C and/or H221Y mutation patterns of HIV-1 reverse transcriptase on phenotypic resistance to available non-nucleoside and nucleoside inhibitors in China

Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase