| Content Provider | MDPI |
|---|---|
| Author | Liao, Han-Tsung Chen, Jyh-Ping Lee, Ming-Yih |
| Abstract | Three-dimensional porous polycaprolactone (PCL) scaffolds with consistent inter-pore channels, 83% porosity and 300–400 μm pore size were fabricated via selective laser sintering. The PCL scaffold was combined with platelet-rich plasma (PRP) to form a bioactive composite and studied for potential application in bone tissue engineering using porcine adipose-derived stem cells (PASCs). The PCL/PRP/PASCs construct showed enhanced cell seeding efficiency and synergistically increased the differentiation capability of PASCs in osteogenic medium toward the osteoblast lineage, judging from elevated alkaline phosphatase activity and up-regulated osteogenic genes expression. For in vivo study, a 3 cm × 3 cm mandible defect was created in pigs and reconstructed by implanting acellular PCL scaffolds or PCL/PRP/PASCs constructs. Both groups showed new bone formation, however, the new bone volume was 5.1 times higher for PCL/PRP/PASCs 6 months post-operation. The bone density was less and loose in the acellular PCL group and the Young’s modulus was only 29% of normal bone. In contrast, continued and compact bone formation was found in PCL/PRP/PASCs and the Young’s modulus was 81% that of normal bone. Masson’s trichrome stain, immunohistochemical analysis of osteocalcin and collagen type I also confirmed new bone formation. |
| File Size | 663552 |
| Ending Page | 4929 |
| Page Count | 19 |
| Starting Page | 4911 |
| File Format | |
| e-ISSN | 19961944 |
| DOI | 10.3390/ma6114911 |
| Journal | Materials |
| Issue Number | 11 |
| Volume Number | 6 |
| Language | English |
| Publisher Date | 2013-10-25 |
| Access Restriction | Open |
| Subject Keyword | bone tissue engineering selective laser sintering polycaprolactone platelet-rich plasma adipose-derived stem cells |
| Content Type | Text |
| Resource Type | Article |
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