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| Content Provider | MDPI |
|---|---|
| Author | Chae, Jae Subedi, Lalita Jeong, Minsun Park, Yong Kim, Chul Kim, Hakwon Kim, Sun |
| Abstract | Gomisin N, one of the lignan compounds found in Schisandra chinensis has been shown to possess anti-oxidative, anti-tumorigenic, and anti-inflammatory activities in various studies. Here we report, for the first time, the anti-melenogenic efficacy of Gomisin N in mammalian cells as well as in zebrafish embryos. Gomisin N significantly reduced the melanin content without cellular toxicity. Although it was not capable of modulating the catalytic activity of mushroom tyrosinase in vitro, Gomisin N downregulated the expression levels of key proteins that function in melanogenesis. Gomisin N downregulated melanocortin 1 receptor (MC1R), adenylyl cyclase 2, microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2). In addition, Gomisin N-treated Melan-A cells exhibited increased p-Akt and p-ERK levels, which implies that the activation of the PI3K/Akt and MAPK/ERK pathways may function to inhibit melanogenesis. We also validated that Gomisin N reduced melanin production by repressing the expression of MITF, tyrosinase, TRP-1, and TRP-2 in mouse and human cells as well as in developing zebrafish embryos. Collectively, we conclude that Gomisin N inhibits melanin synthesis by repressing the expression of MITF and melanogenic enzymes, probably through modulating the PI3K/Akt and MAPK/ERK pathways. |
| File Size | 3220480 |
| File Format | |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms18020471 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 2 |
| Volume Number | 18 |
| Language | English |
| Publisher Date | 2017-02-22 |
| Access Restriction | Open |
| Subject Keyword | Schisandra chinensis Gomisin N lignan melanogenesis skin whitening |
| Content Type | Text |
| Resource Type | Article |
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