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| Content Provider | MDPI |
|---|---|
| Author | Brewer, Christopher Chen, Taosheng |
| Abstract | Herbal supplements are a significant source of drug-drug interactions (DDIs), herb-drug interactions, and hepatotoxicity. Cytochrome P450 (CYP450) enzymes metabolize a large number of FDA-approved pharmaceuticals and herbal supplements. This metabolism of pharmaceuticals and supplements can be augmented by concomitant use of either pharmaceuticals or supplements. The xenobiotic receptors constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) can respond to xenobiotics by increasing the expression of a large number of genes that are involved in the metabolism of xenobiotics, including CYP450s. Conversely, but not exclusively, many xenobiotics can inhibit the activity of CYP450s. Induction of the expression or inhibition of the activity of CYP450s can result in DDIs and toxicity. Currently, the United States (US) Food and Drug Administration does not require the investigation of the interactions of herbal supplements and CYP450s. This review provides a summary of herbal supplements that inhibit CYP450s, induce the expression of CYP450s, and/or whose toxicity is mediated by CYP450s. |
| File Size | 1415168 |
| File Format | |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms18112353 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 11 |
| Volume Number | 18 |
| Language | English |
| Publisher Date | 2017-11-08 |
| Access Restriction | Open |
| Subject Keyword | cytochrome P450 pregnane X receptor constitutive androstane receptor herbal supplement drug-induced liver injury herb-induced liver injury drug-drug interactions drug-herb interactions herb-herb interactions xenobiotic metabolism |
| Content Type | Text |
| Resource Type | Article |
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