NDLI: Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population

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Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population

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Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population

Content Provider	MDPI
Author	Xu, Xiaodong Yue, Ming Jiang, Longfeng Deng, Xiaozhao Zhang, Yongxiang Zhang, Yun Zhu, Danyan Xiao, Wen Zhou, Zhenxian Yao, Wenjuan Kong, Jing Yu, Xiaojie Wei, Juan
Abstract	Chronic hepatitis C is a serious liver disease that often results in cirrhosis or hepatocellular carcinoma. The aim of this study was to assess the association of human leukocyte antigen-DP (HLA-DP) variants with risk of chronic hepatitis C virus (HCV) or anti-F antibody generation. We selected two single nucleotide polymorphisms (SNPs) in a region including HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277534) and genotyped SNPs in 702 cases and 342 healthy controls from the Chinese population using TaqMan SNP genotyping assay. Moreover, the exon 2 of the HLA-DPA1 and HLA-DPB1 genes were amplified and determined by sequencing-based typing (SBT). The results showed that rs3077 significantly increased the risk of chronic HCV infection in additive models and dominant models (odds ratio (OR) = 1.32 and 1.53). The rs3077 also contributed to decrease the risk of anti-F antibody generation in additive models and dominant models (OR = 0.46 and 0.56). Subsequent analyses revealed the risk haplotypes (DPA10103-DPB10501 and DPA10103-DPB10201) and protective haplotypes (DPA10202-DPB10501 and DPA10202-DPB10202) to chronic HCV infection. Moreover, we also found that the haplotype of DPA10103-DPB10201 and DPA10202-DPB10202 were associated with the anti-F antibody generation. Our findings show that genetic variants in HLA-DP gene are associated with chronic HCV infection and anti-F antibody generation.
File Size	251904
Ending Page	9843
Page Count	18
Starting Page	9826
File Format	PDF
e-ISSN	14220067
DOI	10.3390/ijms15069826
Journal	International Journal of Molecular Sciences
Issue Number	6
Volume Number	15
Language	English
Publisher Date	2014-06-03
Access Restriction	Open
Subject Keyword	F protein hepatitis C virus human leukocyte antigen-DP polymorphism
Content Type	Text
Resource Type	Article

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