NDLI: Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions

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Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions

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Three-Dimensional Structural Aspects of Protein–Polysaccharide Interactions

Content Provider	MDPI
Author	Nagae, Masamichi Yamaguchi, Yoshiki
Abstract	Linear polysaccharides are typically composed of repeating mono- or disaccharide units and are ubiquitous among living organisms. Polysaccharide diversity arises from chain-length variation, branching, and additional modifications. Structural diversity is associated with various physiological functions, which are often regulated by cognate polysaccharide-binding proteins. Proteins that interact with linear polysaccharides have been identified or developed, such as galectins and polysaccharide-specific antibodies, respectively. Currently, data is accumulating on the three-dimensional structure of polysaccharide-binding proteins. These proteins are classified into two types: exo-type and endo-type. The former group specifically interacts with the terminal units of polysaccharides, whereas the latter with internal units. In this review, we describe the structural aspects of exo-type and endo-type protein-polysaccharide interactions. Further, we discuss the structural basis for affinity and specificity enhancement in the face of inherently weak binding interactions.
File Size	2600960
Ending Page	3783
Page Count	16
Starting Page	3768
File Format	PDF
e-ISSN	14220067
DOI	10.3390/ijms15033768
Journal	International Journal of Molecular Sciences
Issue Number	3
Volume Number	15
Language	English
Publisher Date	2014-03-03
Access Restriction	Open
Subject Keyword	polysaccharide lectin 3D structure polylactosamine galectin carbohydrate binding module β-glucan polysialic acid antibody affinity hyaluronan CD44
Content Type	Text
Resource Type	Article

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