NDLI: Changes in the Number of Double-Strand DNA Breaks in Chinese Hamster V79 Cells Exposed to γ-Radiation with Different Dose Rates

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Changes in the Number of Double-Strand DNA Breaks in Chinese Hamster V79 Cells Exposed to γ-Radiation with Different Dose Rates

Content Provider	MDPI
Author	Kotenko, Konstantin Bushmanov, Andrey Ozerov, Ivan Guryev, Denis Anchishkina, Natalya Smetanina, Nadezhda Arkhangelskaya, Ekaterina Vorobyeva, Natalya Osipov, Andreyan
Abstract	A comparative investigation of the induction of double-strand DNA breaks (DSBs) in the Chinese hamster V79 cells by γ-radiation at dose rates of 1, 10 and 400 mGy/min (doses ranged from 0.36 to 4.32 Gy) was performed. The acute radiation exposure at a dose rate of 400 mGy/min resulted in the linear dose-dependent increase of the γ-H2AX foci formation. The dose-response curve for the acute exposure was well described by a linear function y = 1.22 + 19.7x, where “y” is an average number of γ-H2AX foci per a cell and “x” is the absorbed dose (Gy). The dose rate reduction down to 10 mGy/min lead to a decreased number of γ-H2AX foci, as well as to a change of the dose-response relationship. Thus, the foci number up to 1.44 Gy increased and reached the “plateau” area between 1.44 and 4.32 Gy. There was only a slight increase of the γ-H2AX foci number (up to 7) in cells after the protracted exposure (up to 72 h) to ionizing radiation at a dose rate of 1 mGy/min. Similar effects of the varying dose rates were obtained when DNA damage was assessed using the comet assay. In general, our results show that the reduction of the radiation dose rate resulted in a significant decrease of DSBs per cell per an absorbed dose.
File Size	294912
Ending Page	13726
Page Count	8
Starting Page	13719
File Format	PDF
e-ISSN	14220067
DOI	10.3390/ijms140713719
Journal	International Journal of Molecular Sciences
Issue Number	7
Volume Number	14
Language	English
Publisher Date	2013-07-01
Access Restriction	Open
Subject Keyword	DNA double-strand breaks γ-Н2АХ foci γ-radiation dose rate effect V79 cells
Content Type	Text
Resource Type	Article

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