NDLI: Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents

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Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents

Content Provider	MDPI
Author	Iriondo-DeHond, Amaia Martorell, Patricia Genovés, Salvador Ramón, Daniel Stamatakis, Konstantinos Fresno, Manuel Molina, Antonio del Castillo, Maria
Abstract	Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector’s sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material.
File Size	2412544
File Format	PDF
e-ISSN	14203049
DOI	10.3390/molecules21060721
Journal	Molecules
Issue Number	6
Volume Number	21
Language	English
Publisher Date	2016-06-01
Access Restriction	Open
Subject Keyword	coffee silverskin oxidative stress UVC radiation chlorogenic acid skin health accelerated aging nutricosmetic dermaceutic
Content Type	Text
Resource Type	Article

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