NDLI: New Trends on Antineoplastic Therapy Research: Bullfrog (Rana catesbeiana Shaw) Oil Nanostructured Systems

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New Trends on Antineoplastic Therapy Research: Bullfrog (Rana catesbeiana Shaw) Oil Nanostructured Systems

Content Provider	MDPI
Author	Amaral-Machado, Lucas Xavier-Júnior, Francisco Rutckeviski, Renata Morais, Andreza Alencar, Éverton Dantas, Teresa Cruz, Ana Genre, Julieta da Silva-Junior, Arnóbio Pedrosa, Matheus Rocha, Hugo Egito, Eryvaldo
Abstract	Bullfrog oil is a natural product extracted from the Rana catesbeiana Shaw adipose tissue and used in folk medicine for the treatment of several diseases. The aim of this study was to evaluate the extraction process of bullfrog oil, to develop a suitable topical nanoemulsion and to evaluate its efficacy against melanoma cells. The oil samples were obtained by hot and organic solvent extraction processes and were characterized by titration techniques and gas chromatography mass spectrometry (GC-MS). The required hydrophile-lipophile balance and the pseudo-ternary phase diagram (PTPD) were assessed to determine the emulsification ability of the bullfrog oil. The anti-tumoral activity of the samples was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for normal fibroblast (3T3) and melanoma (B16F10) cell lines. Both extraction methods produced yielded around 60% and the oil was mainly composed of unsaturated compounds (around 60%). The bullfrog oil nanoemulsion obtained from PTPD presented a droplet size of about 390 nm and polydispersity = 0.05 and a zeta potential of about −25 mV. Both the bullfrog oil itself and its topical nanoemulsion did not show cytotoxicity in 3T3 linage. However, these systems showed growth inhibition in B16F10 cells. Finally, the bullfrog oil presented itself as a candidate for the development of pharmaceutical products free from cytotoxicity and effective for antineoplastic therapy.
File Size	1138688
File Format	PDF
e-ISSN	14203049
DOI	10.3390/molecules21050585
Journal	Molecules
Issue Number	5
Volume Number	21
Language	English
Publisher Date	2016-04-30
Access Restriction	Open
Subject Keyword	bullfrog oil nanomedicine tumor cells nanocarrier
Content Type	Text
Resource Type	Article

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