NDLI: A Synergistic, Balanced Antioxidant Cocktail, Protects Aging Rats from Insulin Resistance and Absence of Meal-Induced Insulin Sensitization (AMIS) Syndrome

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A Synergistic, Balanced Antioxidant Cocktail, Protects Aging Rats from Insulin Resistance and Absence of Meal-Induced Insulin Sensitization (AMIS) Syndrome

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A Synergistic, Balanced Antioxidant Cocktail, Protects Aging Rats from Insulin Resistance and Absence of Meal-Induced Insulin Sensitization (AMIS) Syndrome

Content Provider	MDPI
Author	Wang, Hui Chowdhury, Kawshik Lautt, W.
Abstract	A series of in vivo and in vitro studies using animal and human models in the past 15 years have demonstrated that approximately 55% (~66% in humans) of the glucose disposal effect of an i.v. injection of insulin in the fed state is dependent on the action of a second hormone, hepatic insulin sensitizing substance (HISS), which is released from the liver and stimulates glucose uptake in muscle, heart and kidneys. Sensitization of the insulin response by a meal through release of HISS is called meal-induced insulin sensitization (MIS). Absence of HISS action results in postprandial hyperglycemia, hyperinsulinemia, hyperlipidemia, adiposity, increased free radical stress and a cluster of progressive metabolic and cardiovascular dysfunctions referred to as the AMIS (absence of meal-induced insulin sensitization) syndrome. Reduced HISS release accounts for the insulin resistance that occurs with aging and is made worse by physical inactivity and diets high in sucrose or fat. This brief review provides an update of major metabolic disturbances associated with aging due to reduction of HISS release, and the protection against these pathological changes in aging animals using a balanced synergistic antioxidant cocktail SAMEC (S-adenosylmethionine, vitamins E and C). The synergy amongst the components is consistent with the known benefits of antioxidants supplied by a mixed diet and acting through diverse mechanisms. Using only three constituents, SAMEC appears suitable as an antioxidant specifically targeting the AMIS syndrome.
File Size	830464
Ending Page	682
Page Count	14
Starting Page	669
File Format	PDF
e-ISSN	14203049
DOI	10.3390/molecules20010669
Journal	Molecules
Issue Number	1
Volume Number	20
Language	English
Publisher Date	2015-01-06
Access Restriction	Open
Subject Keyword	HISS-dependent insulin resistance (HDIR) Meal-induced Insulin Sensitization (MIS) Absence of Meal-induced Insulin Sensitization (AMIS) Hepatic Insulin Sensitizing Substance (HISS) S-adenosylmethionine vitamins E and C (SAMEC)
Content Type	Text
Resource Type	Article

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