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| Content Provider | MDPI |
|---|---|
| Author | De Rosa, Margherita Vigliotta, Giovanni Palma, Giuseppe Saturnino, Carmela Soriente, Annunziata |
| Abstract | The synthesis and the biological activity of novel semi-synthetic β-lactam compounds containing an azetidinone moiety joined to the amino-nitrogen of the (+)-6-aminopenicillanic acid (6-APA) as new antibacterial agents is reported. The synthesized compounds were screened for their in vitro antimicrobial activity against a panel of Gram positive and Gram negative pathogens and environmental bacteria. Tested compounds displayed good antimicrobial activity against all tested Gram positive bacteria and for Staphylococcus aureus and Staphylococcus epidermidis antimicrobial activity resulted higher than that of the reference antibiotic. Additionally, in vitro cytotoxic screening was also carried out indicating that the compounds do not cause a cell vitality reduction effective at concentration next to and above those shown to be antimicrobial. |
| File Size | 1073152 |
| Ending Page | 22057 |
| Page Count | 14 |
| Starting Page | 22044 |
| File Format | |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules201219828 |
| Journal | Molecules |
| Issue Number | 12 |
| Volume Number | 20 |
| Language | English |
| Publisher Date | 2015-12-10 |
| Access Restriction | Open |
| Subject Keyword | 6-aminopenicillanic acid (6-APA) 2-azetidinone β-lactam antibiotics antibacterial Staudinger reaction |
| Content Type | Text |
| Resource Type | Article |
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