NDLI: Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy

Content Provider	Journal of Biological Chemistry (JBC)
Author	Zuo, Ru-Juan Gu, Xiao-Wei Qi, Qian-Rong Wang, Tong-Song Zhao, Xu-Yu Liu, Ji-Long Yang, Zeng-Ming
Abstract	Decidualization is an essential process of maternal endometrial stromal cells to support pregnancy. Although it is known that enhanced glucose influx is critical for decidualization, the underlying mechanism in regulating glucose metabolism in decidua remains insufficiently understood. Here, we demonstrate that aerobic glycolysis-related genes and factors are all substantially induced during decidualization, indicating the existence of Warburg-like glycolysis in decidua. In vitro, progesterone activates hypoxia-inducible factor 1α (Hif1α) and c-Myc through Pi3k-Akt signaling pathway to maintain aerobic glycolysis in decidualizing cells. Knocking down of pyruvate kinase M2 (Pkm2) attenuates the induction of decidual marker gene. Decidual formation in vivo is also impaired by glycolysis inhibitor 3-bromopyruvate. Besides, lactate exporter monocarboxylate transporter 4 (Mct4) is induced in newly formed decidual cells, whereas lactate importer Mct1 and proliferation marker Ki-67 are complementarily located in the surrounding undifferentiated cells, which are supposed to consume lactate for proliferation. Hif1α activation is required for lactate-dependent proliferation of the undifferentiated cells. Inhibition of lactate flux leads to compromised decidualization and decelerated lactate-dependent proliferation. In summary, we reveal that Warburg-like glycolysis and local lactate shuttle are activated in decidua and play important roles for supporting early pregnancy.
Related Links	http://www.jbc.org/content/290/35/21280.abstract
Ending Page	21291
Starting Page	21280
Page Count	12
File Format	HTM / HTML PDF
ISSN	00219258
Journal	Journal of Biological Chemistry (JBC)
Issue Number	35
Volume Number	290
DOI	10.1074/jbc.M115.656629
e-ISSN	1083351X
Language	English
Publisher	American Society for Biochemistry and Molecular Biology
Publisher Date	2015-08-28
Access Restriction	Open
Subject Keyword	Carbohydrate metabolism Glycolysis Pregnancy Reproduction Warburg effect Warburg-like glycolysis Lactate flux Decidualization Hif1α Progesterone Metabolism
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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