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| Content Provider | Journal of Biological Chemistry (JBC) |
|---|---|
| Author | Ito, Keiichi Yamazaki, Satoshi Yamamoto, Ryo Tajima, Yoko Yanagida, Ayaka Kobayashi, Toshihiro Kato-Itoh, Megumi Kakuta, Shigeru Iwakura, Yoichiro Nakauchi, Hiromitsu Kamiya, Akihide |
| Abstract | Identification of genes specifically expressed in stem/progenitor cells is an important issue in developmental and stem cell biology. Genome-wide gene expression analyses in liver cells performed in this study have revealed a strong expression of X-linked genes that include members of the brain-expressed X-linked (Bex) gene family in stem/progenitor cells. Bex family genes are expressed abundantly in the neural cells and have been suggested to play important roles in the development of nervous tissues. However, the physiological role of its individual members and the precise expression pattern outside the nervous system remain largely unknown. Here, we focused on Bex2 and examined its role and expression pattern by generating knock-in mice; the enhanced green fluorescence protein (EGFP) was inserted into the Bex2 locus. Bex2-deficient mice were viable and fertile under laboratory growth conditions showing no obvious phenotypic abnormalities. Through an immunohistochemical analysis and flow cytometry-based approach, we observed unique EGFP reporter expression patterns in endocrine and stem/progenitor cells of the liver, pyloric stomach, and hematopoietic system. Although Bex2 seems to play redundant roles in vivo, these results suggest the significance and potential applications of Bex2 in studies of endocrine and stem/progenitor cells. |
| Related Links | http://www.jbc.org/content/289/43/29892.abstract |
| Ending Page | 29911 |
| Starting Page | 29892 |
| Page Count | 20 |
| File Format | HTM / HTML PDF |
| ISSN | 00219258 |
| Journal | Journal of Biological Chemistry (JBC) |
| Issue Number | 43 |
| Volume Number | 289 |
| DOI | 10.1074/jbc.M114.580084 |
| e-ISSN | 1083351X |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2014-10-24 |
| Access Restriction | Open |
| Subject Keyword | Development Gene Expression Gene Knock-out Hematopoietic Stem Cells Liver Stem Cells Brain-expressed X-linked Gene X-linked Gene Endocrine Cells Gene Regulation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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