NDLI: Identification and Characterization of Novel Mammalian Neuropeptide FF-like Peptides That Attenuate Morphine-induced Antinociception

Content Provider	Journal of Biological Chemistry (JBC)
Author	Liu, Qingyun Guan, Xiao-Ming Martin, William J. McDonald, Terrence P. Clements, Michelle K. Jiang, Qingping Zeng, Zhizhen Jacobson, Marlene Jr, David L. Williams Yu, Hong Bomford, Douglas Figueroa, David Mallee, John Wang, Ruiping Evans, Jilly Gould, Robert Austin, Christopher P. Williams, David L.
Abstract	The two mammalian neuropeptides NPFF and NPAF have been shown to have important roles in nociception, anxiety, learning and memory, and cardiovascular reflex. Two receptors (FF1 and FF2) have been molecularly identified for NPFF and NPAF. We have now characterized a novel gene designated NPVF that encodes two neuropeptides highly similar to NPFF. NPVF mRNA was detected specifically in a region between the dorsomedial and ventromedial hypothalamic nuclei. NPVF-derived peptides displayed higher affinity for FF1 than NPFF-derived peptides, but showed poor agonist activity for FF2. Following intracerebral ventricular administration, a NPVF-derived peptide blocked morphine-induced analgesia more potently than NPFF in both acute and inflammatory models of pain. In situ hybridization analysis revealed distinct expression patterns of FF1 and FF2 in the rat central nervous system. FF1 was broadly distributed, with the highest levels found in specific regions of the limbic system and the brainstem where NPVF-producing neurons were shown to project. FF2, in contrast, was mostly expressed in the spinal cord and some regions of the thalamus. These results indicate that the endogenous ligands for FF1 and FF2 are NPVF- and NPFF-derived peptides, respectively, and suggest that the NPVF/FF1 system may be an important part of endogenous anti-opioid mechanism.
Related Links	http://www.jbc.org/content/276/40/36961.abstract
Ending Page	36969
Starting Page	36961
Page Count	9
File Format	HTM / HTML PDF
ISSN	00219258
Journal	Journal of Biological Chemistry (JBC)
Issue Number	40
Volume Number	276
DOI	10.1074/jbc.M105308200
e-ISSN	1083351X
Language	English
Publisher	American Society for Biochemistry and Molecular Biology
Publisher Date	2001-10-05
Access Restriction	Open
Subject Keyword	Phe-Met-Arg-Phe-NH2 (FMRFamide) Phe-Met-Arg-Phe-NH2-related peptide (FaRP) Leu-Pro-Leu-Arg-Phe-NH2 (LPLRFa) Intracerebral ventricular (ICV) Central nervous system (CNS) Chinese hamster ovary (CHO) Nuclear factor of activated T cells (NFAT) Expressed sequence tag (EST) Fluorescence imaging plate reader (FLIPR) MECHANISMS OF SIGNAL TRANSDUCTION
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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