NDLI: Identification and Characterization of KLK-L4, a New Kallikrein-like Gene That Appears to be Down-regulated in Breast Cancer Tissues

Content Provider	Journal of Biological Chemistry (JBC)
Author	Yousef, George M. Chang, Albert Diamandis, Eleftherios P.
Abstract	Kallikreins are a subgroup of serine proteases and these proteolytic enzymes have diverse physiological functions in many tissues. Growing evidence suggests that many kallikreins are implicated in carcinogenesis. In rodents, kallikreins constitute a large multigene family, but in humans, only three genes were identified. By using the positional candidate gene approach, we were able to identify a new kallikrein-like gene, tentatively namedKLK-L4 (for kallikrein-like gene 4). This new gene maps to chromosome 19q13.3-q13.4, is formed of five coding exons and four introns, and shows structural similarity to other kallikreins and kallikrein-like genes. KLK-L4 is expressed in a variety of tissues including prostate, salivary gland, breast, and testis. Our preliminary results show that KLK-L4 is down-regulated, at the mRNA level, in breast cancer tissues and breast cancer cell lines. Its expression is regulated by steroid hormones in the breast cancer cell line BT-474. This gene may be involved in the pathogenesis and/or progression of breast cancer and may find applicability as a novel cancer biomarker.
Related Links	http://www.jbc.org/content/275/16/11891.abstract
Ending Page	11898
Starting Page	11891
Page Count	8
File Format	HTM / HTML PDF
ISSN	00219258
Journal	Journal of Biological Chemistry (JBC)
Issue Number	16
Volume Number	275
DOI	10.1074/jbc.275.16.11891
e-ISSN	1083351X
Language	English
Publisher	American Society for Biochemistry and Molecular Biology
Publisher Date	2000-04-21
Access Restriction	Open
Subject Keyword	Prostate-specific antigen (PSA) Kallikrein (KLK) Kilobase (kb) Kallikrein-like (KLK-L) Expressed sequence tag (EST) Rapid amplification of cDNA ends (RACE) Polymerase chain reaction (PCR) Base pair(s) (bp) Reverse transcription (RT) Trypsin-like serine protease (TLSP) GENES: STRUCTURE AND REGULATION
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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