NDLI: Structure of Cardiac Muscle Troponin C Unexpectedly Reveals a Closed Regulatory Domain

Content Provider	Journal of Biological Chemistry (JBC)
Author	Sia, Samuel K. Li, Monica X. Spyracopoulos, Leo Gagné, Stéphane M. Liu, Wen Putkey, John A. Sykes, Brian D.
Abstract	The regulation of cardiac muscle contraction must differ from that of skeletal muscles to effect different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator of cardiac muscle contraction, possesses different functional and Ca2+-binding properties compared with skeletal TnC and features a Ca2+-binding site I, which is naturally inactive. The structure of cardiac TnC in the Ca2+-saturated state has been determined by nuclear magnetic resonance spectroscopy. The regulatory domain exists in a “closed” conformation even in the Ca2+-bound (the “on”) state, in contrast to all predicted models and differing significantly from the calcium-induced structure observed in skeletal TnC. This structure in the Ca2+-bound state, and its subsequent interaction with troponin I (TnI), are crucial in determining the specific regulatory mechanism for cardiac muscle contraction. Further, it will allow for an understanding of the action of calcium-sensitizing drugs, which bind to cardiac TnC and are known to enhance the ability of cardiac TnC to activate cardiac muscle contraction.
Related Links	http://www.jbc.org/content/272/29/18216.abstract
Ending Page	18221
Starting Page	18216
Page Count	6
File Format	HTM / HTML PDF
ISSN	00219258
Journal	Journal of Biological Chemistry (JBC)
Issue Number	29
Volume Number	272
DOI	10.1074/jbc.272.29.18216
e-ISSN	1083351X
Language	English
Publisher	American Society for Biochemistry and Molecular Biology
Publisher Date	1997-07-18
Access Restriction	Open
Subject Keyword	PROTEIN CHEMISTRY AND STRUCTURE
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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Kinetic Studies of Calcium Binding to the Regulatory Site of Troponin C from Cardiac Muscle

Solution Structure and Main Chain Dynamics of the Regulatory Domain (Residues 1–91) of Human Cardiac Troponin C

Structural Dynamics of C-domain of Cardiac Troponin I Protein in Reconstituted Thin Filament

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A Direct Regulatory Role for Troponin T and a Dual Role for Troponin C in the Ca2+ Regulation of Muscle Contraction

A Kinetic Model for the Binding of Ca2+ to the Regulatory Site of Troponin from Cardiac Muscle

Structure and Dynamics of the C-domain of Human Cardiac Troponin C in Complex with the Inhibitory Region of Human Cardiac Troponin I

Conformation of the Regulatory Domain of Cardiac Muscle Troponin C in Its Complex with Cardiac Troponin I

Structure of Cardiac Muscle Troponin C Unexpectedly Reveals a Closed Regulatory Domain

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