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| Content Provider | Journal of Biological Chemistry (JBC) |
|---|---|
| Author | Mizushima, Tohru Ishikawa, Yuichi Obana, Eishi Hase, Masakazu Kubota, Toshio Katayama, Tsutomu Kunitake, Toyoki Watanabe, Eiji Sekimizu, Kazuhisa |
| Abstract | DnaA protein is the initiator of chromosomal DNA replication in Escherichia coli. We examined the influence of artificial mixed membrane composed of synthetic acidic (phosphate) lipid and basic (ammonium) lipid on the affinity of DnaA protein for ATP. Two sets of acidic and basic lipids with distinguishable numbers of hydrophobic alkyl chains were devised. Synthetic membranes made of the sole acidic lipid but not the basic bilayers inhibited the ATP binding to DnaA protein and stimulated the release of ATP from the ATP-DnaA complex. The basic bilayer-forming compounds served as the matrix for the guest acidic lipids. Acidic lipids dispersed in the basic matrix membrane had little effect on ATP binding and on ATP release. Conversely, acidic lipids forming cluster structures in the mixed artificial membranes inhibited the ATP binding and stimulated the release of ATP. These observations suggest that in mixed lipid bilayers, a cluster structure of acidic lipids seems to be an important parameter to decrease the affinity of DnaA protein for ATP. |
| Related Links | http://www.jbc.org/content/271/7/3633.abstract |
| Ending Page | 3638 |
| Starting Page | 3633 |
| Page Count | 6 |
| File Format | HTM / HTML PDF |
| ISSN | 00219258 |
| Journal | Journal of Biological Chemistry (JBC) |
| Issue Number | 7 |
| Volume Number | 271 |
| DOI | 10.1074/jbc.271.7.3633 |
| e-ISSN | 1083351X |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 1996-02-16 |
| Access Restriction | Open |
| Subject Keyword | Membranes and Bioenergetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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