NDLI: Cytochrome c Oxidase Subunit VIIa Liver Isoform CHARACTERIZATION AND IDENTIFICATION OF PROMOTER ELEMENTS IN THE BOVINE GENE

Content Provider	Journal of Biological Chemistry (JBC)
Author	Seelan, R. Sathiagana Gopalakrishnan, Lekha Scarpulla, Richard C. Grossman, Lawrence I.
Abstract	Cytochrome c oxidase subunit VIIa is specified by two nuclear genes, one (COX7AH) producing a heart/muscle-specific isoform and the other (COX7AL) a form expressed in all tissues. We have isolated both genes to examine their transcriptional regulation. Here, we characterize the core promoter of COX7AL and show that a 92-base pair region flanking the 5′-end promotes most of the activity of this gene. The 92-bp basal promoter contains sites for the nuclear respiratory factors NRF-1 and NRF-2, which have been shown to contribute to the transcription of a number of nuclear genes involved in mitochondrial respiratory activity, and also at least four Sp1 motifs. We show that both the NRF-1 and NRF-2 binding sites are functional in COX7AL and present evidence suggesting that interaction between the NRF-1 site and an upstream element contributes to expression.
Related Links	http://www.jbc.org/content/271/4/2112.abstract
Ending Page	2120
Starting Page	2112
Page Count	9
File Format	HTM / HTML PDF
ISSN	00219258
Journal	Journal of Biological Chemistry (JBC)
Issue Number	4
Volume Number	271
DOI	10.1074/jbc.271.4.2112
e-ISSN	1083351X
Language	English
Publisher	American Society for Biochemistry and Molecular Biology
Publisher Date	1996-01-26
Access Restriction	Open
Subject Keyword	Nucleic Acids, Protein Synthesis, and Molecular Genetics
Alternative Title	Cytochrome c Oxidase Subunit VIIa Liver Isoform
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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