NDLI: Factor Analysis of the National Institutes of Health Stroke Scale in Patients With Large Strokes

Content Provider	JAMA Network
Author	Lyden, Patrick Claesson, Lennart Havstad, Suzanne Ashwood, Tim Lu, Mei
Copyright Year	2004
Abstract	Background: The National Institutes of Health Stroke Scale ( NIHSS) was created to detect treatment-related differences in clinical trials and was designed to measure right- and left-sided cerebral hemispheric function. Objective: To validate the original design in patients with very large strokes. Design: A previously published factor structure was fit to the data. Then, a new analysis was conducted to explore the underlying structure of the scale in this population. Finally, NIHSS scores and infarction volumes were compared. Setting: The Clomethiazole for Acute Stroke Study– Ischemic, conducted in academic and community hospitals. Patients: Individuals with acute stroke seen within 12 hours of onset. Of 1191 records available, 98% had complete NIHSS scores. Main Outcome Measure: Goodness-of-fit statistic ( Bentler) for each factor solution. Results: Two factors were found underlying the NIHSS, corresponding to the left and right hemispheres (goodness of fit = 0.97), using the previously published factor analysis. The new exploratory analysis also suggested 2 factors representing left and right brain function. The median (range) NIHSS scores were 15 (5-25) for right brain strokes and 19 (6-32) for left brain strokes ( P<.001). The median (range) infarction volumes were 56.2 m: L (0.1-381.5 m: L) for right brain strokes and 37.8 m: L (0.2-255.1 m: L) for left brain strokes ( P<.001). The correlation coefficient between NIHSS score and lesion volume was 0.37 ( P<.001). Conclusions: The underlying structure of the NIHSS conforms to cerebral hemispheric lateralization, confirming previous findings in a new population of large hemispheric strokes. Left- brain strokes score 4 points higher on the NIHSS than right brain strokes of larger volume.
Ending Page	1680
Starting Page	1677
Page Count	4
File Format	PDF HTM / HTML
ISSN	00039942
DOI	10.1001/archneur.61.11.1677
Issue Number	11
Journal	Archives of Neurology
Volume Number	61
Language	English
Publisher	American Medical Association
Publisher Date	2004-11-01
Access Restriction	Open
Subject Keyword	cerebrovascular accident nih stroke scale infarction goodness of fit acute cerebrovascular accidents right cerebral hemisphere chlormethiazole ischemia
Content Type	Text
Resource Type	Article
Subject	1200/1201 Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Prediction of Hospital Disposition After Thrombolysis for Acute Ischemic Stroke Using the National Institutes of Health Stroke Scale

Endovascular Treatment for Patients With Acute Stroke Who Have a Large Ischemic Core and Large Mismatch Imaging Profile

Diffusion-Weighted Imaging and National Institutes of Health Stroke Scale in the Acute Phase of Posterior-Circulation Stroke

Neurologic Worsening During the Acute Phase of Ischemic Stroke

Thrombolysis in Patients With Marked Clinical Fluctuations in Neurologic Status Due to Cerebral Ischemia

Association of Higher Serum Calcium Levels With Smaller Infarct Volumes in Acute Ischemic Stroke

Association of Aspirin Resistance With Increased Stroke Severity and Infarct Size

Atherosclerotic Burden and Early Mortality in Acute Ischemic Stroke

Venturi Mask Adjuvant Oxygen Therapy in Severe Acute Ischemic Stroke

Factor Analysis of the National Institutes of Health Stroke Scale in Patients With Large Strokes

Similar Documents

Prediction of Hospital Disposition After Thrombolysis for Acute Ischemic Stroke Using the National Institutes of Health Stroke Scale

Endovascular Treatment for Patients With Acute Stroke Who Have a Large Ischemic Core and Large Mismatch Imaging Profile

Diffusion-Weighted Imaging and National Institutes of Health Stroke Scale in the Acute Phase of Posterior-Circulation Stroke

Neurologic Worsening During the Acute Phase of Ischemic Stroke

Thrombolysis in Patients With Marked Clinical Fluctuations in Neurologic Status Due to Cerebral Ischemia

Association of Higher Serum Calcium Levels With Smaller Infarct Volumes in Acute Ischemic Stroke

Association of Aspirin Resistance With Increased Stroke Severity and Infarct Size

Atherosclerotic Burden and Early Mortality in Acute Ischemic Stroke

Venturi Mask Adjuvant Oxygen Therapy in Severe Acute Ischemic Stroke

Factor Analysis of the National Institutes of Health Stroke Scale in Patients With Large Strokes