NDLI: Multiple Hormonal Responses to Protirelin (TRH) in Depressed Patients

Content Provider	JAMA Network
Author	Winokur, Andrew Amsterdam, Jay D. Oler, Jacqueline Mendels, Joe Snyder, Peter J. Caroff, Stanley N. Brunswick, David J.
Copyright Year	1983
Abstract	• The effects of protirelin (thyrotropin-releasing hormone [ TRH]) administration on the release of five pituitary hormones (thyrotropin [ TSH], prolactin [ Prol], growth hormone, luteinizing hormone, and follicle-stimulating hormone [ FSH]) were examined in 45 patients with major depressive disorder and 32 healthy volunteers. Although mean pituitary responses to protirelin in depressed patients and controls appeared to be comparable, depressed patients had higher SDs in all cases. Twelve patients (26.7%) but no controls had two or more abnormal hormonal responses to protirelin administration. The use of several nonparametric analyses revealed significant differences in patterns of hormonal response between depressed patients and controls for TSH, Prol, and FSH. These findings support the hypothesis that increased variability of neuroendocrine responsiveness represents a fundamental aspect of physiologic function in patients with endogenous depression.
Ending Page	531
Starting Page	525
Page Count	7
File Format	PDF HTM / HTML
ISSN	0003990X
DOI	10.1001/archpsyc.1983.01790050051006
Issue Number	5
Journal	Archives of General Psychiatry
Volume Number	40
Language	English
Publisher	American Medical Association
Publisher Date	1983-05-01
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	1200/1201 Psychiatry and Mental Health

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