NDLI: Impact on Quality of Life of Botulinum Toxin Treatments for Spasmodic Dysphonia and Oromandibular Dystonia

Content Provider	JAMA Network
Author	Bhattacharyya, Neil Tarsy, Daniel
Copyright Year	2001
Abstract	Objective: To determine the impact on quality of life of botulinum toxin treatments for common dystonias of the head and neck. Design: Cross-sectional survey study of a patient cohort treated with botulinum toxin injections for spasmodic dysphonia ( SD) or oromandibular dystonia ( OMD). Interventions and Outcome Measures: The Glasgow Benefit Inventory was used to quantify the health benefit of treatment. Data were collected for demographics, time intervals relative to diagnosis, treatment duration, and frequency of injections. The groups were compared to determine whether differences existed in benefit from treatment. Correlation analysis was conducted for inventory scores and time intervals. Results: A total of 23 patients (5 with OMD and 18 with SD) completed the questionnaire. The mean total benefit score was +38.04 (possible range, −100 to +100) for the whole group ( P<.001). The OMD group derived a nonsignificantly smaller benefit (+21.67 vs +42.59) ( P= .07). The mean subscores for the combined group were +39.67, +26.81, and +42.75 for the general, social support, and physical health subscores, respectively ( P≤.001). The difference in mean subscores between the 2 groups was not statistically significant, although patients with OMD had a lower social support subscore (+6.67 vs +32.41). No correlation was found between duration of therapy or frequency of injections and the Glasgow Benefit Inventory score. Conclusions: Patients with OMD or SD derive considerable benefit when treated with botulinum toxin. The magnitude of benefit is largely independent of the time course of therapy. Treatment with botulinum toxin for these conditions is effective on the basis of quality-of-life criteria.
Ending Page	392
Starting Page	389
Page Count	4
File Format	PDF HTM / HTML
ISSN	08864470
DOI	10.1001/archotol.127.4.389
Issue Number	4
Journal	Archives of Otolaryngology–Head & Neck Surgery
Volume Number	127
Language	English
Publisher	American Medical Association
Publisher Date	2001-04-01
Access Restriction	Open
Subject Keyword	botulinum toxins quality of life spastic dysphonia oromandibular dystonia duration of treatment dystonia physical health
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Surgery

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