NDLI: Clinical Significance, Pathogenesis, and Management of Postprandial Hyperglycemia

Content Provider	JAMA Network
Author	Gerich, John E.
Copyright Year	2003
Abstract	It is well established that strict glycemic control (hemoglobin A1c<7.0%) can prevent the microvascular complications of diabetes mellitus. Recent studies indicate that elevated plasma glucose concentrations are an independent and clinically significant risk factor for cardiovascular disease in nondiabetic and diabetic individuals. Thus, isolated postprandial hyperglycemia (2-hour postprandial glucose level >140 mg/d: L [>7.8 mmol/ L]) in the face of normal fasting plasma glucose (<110 mg/d: L [<6.1 mmol/ L]) and normal hemoglobin A1c(<6.1%) values is associated with a 2-fold increased risk of death from cardiovascular disease. These observations imply that more strict glycemic control is required to prevent macrovascular disease than microvascular disease. This review summarizes epidemiologic and experimental studies linking postprandial hyperglycemia to cardiovascular disease and therapeutic approaches available and in development to treat this disorder.
Ending Page	1316
Starting Page	1306
Page Count	11
File Format	PDF HTM / HTML
ISSN	00039926
DOI	10.1001/archinte.163.11.1306
Issue Number	11
Journal	Archives of Internal Medicine
Volume Number	163
Language	English
Publisher	American Medical Association
Publisher Date	2003-06-09
Access Restriction	Open
Subject Keyword	cardiovascular diseases hyperglycemia type 2 diabetes mellitus glucose insulin plasma glucose postprandial hyperglycemia diabetes mellitus glucose control fasting glycosylated hemoglobin a cardiovascular disease risk factors postprandial period
Content Type	Text
Resource Type	Article
Subject	Internal Medicine

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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