NDLI: Autoimmune Thrombocytopenic Purpura and Helicobacter pylori Infection

Content Provider	JAMA Network
Author	Michel, Marc Khellaf, Mehdi Desforges, Lionel Lee, Ketty Schaeffer, Annette Godeau, Bertrand Bierling, Philippe
Copyright Year	2002
Abstract	Background: The mechanisms triggering the production of platelet autoantibodies in autoimmune thrombocytopenic purpura ( AITP) are poorly understood. Recently, marked improvements in platelet counts have been reported in patients with AITP and concurrent: Helicobacter pyloriinfection after eradication of: H pyloriby a standard antibiotic regimen. We looked for an association between: H pyloriinfection and AITP in adults. Methods: Fifty-one adults of white French origin, negative for human immunodeficiency virus (mean ± SD age, 40 ± 19.8 years), with AITP and a platelet count of less than 50 × 103/µ L at onset were included. Thirty-five consecutive nonthrombocytopenic patients (mean ± SD age, 43 ± 22 years) of the same origin and with unknown: H pyloristatus served as control subjects. Antibodies against: H pyloriwere detected by means of an agglutination method in both patients and control subjects. Sex ratio, mean age, hemorrhagic manifestations, response to corticosteroid therapy, and final outcome were compared in: H pylori–negative and: H pylori–positive patients with AITP. To test for a possible molecular mimicry mechanism, we also used an immunoblot assay to look for specific: H pyloriantibodies in platelet eluates from 3H pylori–positive patients with AITP. Results: Seroprevalence of: H pyloriin patients with AITP (15 [29%]) was not significatively different from that in control subjects (10 [29%]). The: H pylori–positive and: H pylori–negative patients with AITP did not differ in main characteristics at AITP onset, response rate to corticosteroids, and final outcome. None of the 3 patients investigated had: H pyloriantibodies in platelet eluates. Conclusion: Although the role of: H pyloriin a subgroup of patients with AITP cannot be excluded, we found no evidence of an association between: H pyloriinfection and AITP.
Ending Page	1036
Starting Page	1033
Page Count	4
File Format	PDF HTM / HTML
ISSN	00039926
DOI	10.1001/archinte.162.9.1033
Issue Number	9
Journal	Archives of Internal Medicine
Volume Number	162
Language	English
Publisher	American Medical Association
Publisher Date	2002-05-13
Access Restriction	Open
Subject Keyword	blood platelets helicobacter pylori helicobacter infections purpura, thrombocytopenic, idiopathic antibodies autoantibodies platelet count measurement glucocorticoids antibiotics immunoblotting
Content Type	Text
Resource Type	Article
Subject	Internal Medicine

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