NDLI: Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder

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Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder

Content Provider	JAMA Network
Author	Milak, Matthew S. Parsey, Ramin V. Keilp, John Oquendo, Maria A. Malone, Kevin M. Mann, J. John
Copyright Year	2005
Abstract	Background: The Hamilton Depression Rating Scale ( HDRS) is widely used to measure the severity of depression in mood disorders. Total HDRS score correlates with brain metabolism as measured by fludeoxyglucose F 18 ([18F]- FDG) positron emission tomography. The HDRS comprises distinct symptom clusters that may be associated with different patterns of regional brain glucose metabolism. Objective: To examine associations between HDRS component psychopathologic clusters and resting glucose cerebral metabolism assessed by [18F]- FDG positron emission tomography. Patients: We evaluated 298 drug-free patients who met the: DSM- III- Rcriteria for major depressive disorder. Main Outcome Measures: Five principal components were extracted from the 24-item HDRS for all subjects and Pro: Max rotated: psychic depression, loss of motivated behavior, psychosis, anxiety, and sleep disturbance. The [18F]- FDG scans were acquired in a subgroup of 43 drug-free patients in twelve 5-minute frames. Voxel-level correlation maps were generated with HDRS total and factor scores. Results: Total HDRS score correlated positively with activity in a large bilateral ventral cortical and subcortical region that included limbic, thalamic, and basal ganglia structures. Distinct correlation patterns were found with the 3 individual HDRS factors. Psychic depression correlated positively with metabolism in the cingulate gyrus, thalamus, and basal ganglia. Sleep disturbance correlated positively with metabolism in limbic structures and basal ganglia. Loss of motivated behavior was negatively associated with parietal and superior frontal cortical areas. Conclusions: Different brain regions correlate with discrete symptom components that compose the overall syndrome of major depression. Future studies should extend knowledge about specific regional networks by identifying responsible neurotransmitters related to specific psychopathologic components of mood disorders.
Ending Page	408
Starting Page	397
Page Count	12
File Format	PDF HTM / HTML
ISSN	0003990X
DOI	10.1001/archpsyc.62.4.397
Issue Number	4
Journal	Archives of General Psychiatry
Volume Number	62
Language	English
Publisher	American Medical Association
Publisher Date	2005-04-01
Access Restriction	Open
Subject Keyword	fibrinogen depressive disorders dyssomnias major depressive disorder voxel sleep disorders positron-emission tomography brain hamilton rating scale for depression fluorodeoxyglucose f18 glucose thalamus neurotransmitters subcortical anxiety psychotic disorders metabolism limbic system
Content Type	Text
Resource Type	Article
Subject	1200/1201 Psychiatry and Mental Health

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