NDLI: Serotypes of Chlamydia trachomatis and Risk for Development of Cervical Squamous Cell Carcinoma

Content Provider	JAMA Network
Author	Anttila, Tarja Saikku, Pekka Koskela, Pentti Bloigu, Aini Dillner, Joakim Ikäheimo, Irma Jellum, Egil Lehtinen, Matti Lenner, Per Hakulinen, Timo Närvänen, Ale Pukkala, Eero Thoresen, Steinar Youngman, Linda Paavonen, Jorma
Copyright Year	2001
Abstract	Context: Human papillomavirus ( HPV) infection has been established as a cause of cervical cancer. Epidemiologic studies suggest that Chlamydia trachomatis infection also confers increased risk for cervical squamous cell carcinoma ( SCC). Whether this risk is serotype-specific is unknown. Objective: To study the association between exposure to different C trachomatis serotypes and subsequent development of cervical SCC. Design and Setting: Longitudinal, nested case-control study within a cohort of 530 000 women who provided samples to serum banks in Finland, Norway, and Sweden. The data files were linked to respective national cancer registries. Subjects: One hundred twenty-eight women who had developed invasive cervical SCC at least 12 months following serum donation. Each case had 3 matched controls. Main Outcome Measure: Risk for the development of cervical SCC by Ig: G antibodies to 10 different C trachomatis serotypes, adjusted for antibodies to HPV types 16, 18, and 33 and for serum cotinine levels. Results: Of specific C trachomatis serotypes, serotype G was most strongly associated with SCC (adjusted odds ratio [ OR], 6.6; 95% confidence interval [ CI], 1.6-27.0). Other serotypes associated with SCC were I ( OR, 3.8; 95% CI, 1.3-11.0) and D ( OR, 2.7; 95% CI, 1.3-5.6). Presence of serum Ig: G antibodies to more than 1 serotype increased the adjusted ORs for SCC ( P<.001 for trend). Conclusions: Chlamydia trachomatis serotype G is most strongly associated with subsequent development of cervical SCC. Increasing numbers of exposures to different C trachomatis serotypes also increases risk. Our results strengthen the evidence that there is a link between past C trachomatis infection and cervical SCC.
Ending Page	51
Starting Page	47
Page Count	5
File Format	PDF HTM / HTML
ISSN	00987484
DOI	10.1001/jama.285.1.47
Issue Number	1
Journal	JAMA
Volume Number	285
Language	English
Publisher	American Medical Association
Publisher Date	2001-01-03
Access Restriction	Open
Subject Keyword	chlamydia trachomatis cotinine cervical cancer antibodies squamous cell carcinoma of cervix serotype infection igg antibody chlamydia trachomatis infections cancer human papillomavirus finland norway
Content Type	Text
Resource Type	Article
Subject	Medicine

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