NDLI: Increasing Lymphatic Microvessel Density in Primary Pterygia

Content Provider	JAMA Network
Author	Ling, Shiqi Liang, Lingyi Lin, Haotian Li, Weihua Xu, Jiangang
Copyright Year	2012
Abstract	Objective: To examine lymphatic microvessel density ( LMVD) in primary pterygia. Methods: We included tissue samples from 88 excised primary (including 34 grade 1, 28 grade 2, and 26 grade 3) pterygia and from 7 nasal epibulbar conjunctivae segments used as control samples. Sections from each pterygium were immunostained with CD31 and lymphatic vessel endothelial hyaluronan receptor 1 ( LYVE-1) monoclonal antibodies to evaluate LMVD and blood microvessel density. We used real-time polymerase chain reaction analysis to measure expression of vascular endothelial growth factor A ( VEGF- A) and VEGF- C messenger RNA (m: RNA) in the pterygia. Results: A small number of CD31-positive LYVE-1–negative blood vessels and only a few CD31- and LYVE-1–positive lymphatic vessels were detected in the normal epibulbar conjunctiva segments. Lymphatic vessels were mildly increased in grade 1 pterygia but were dramatically increased in grades 2 and 3 pterygia. Lymphatic microvessel density correlated closely with blood microvessel density in grades 1, 2, and 3 pterygia ( P < .05 for all). The width and area of pterygia were significantly correlated with LMVD. In addition, we found a significant relationship between VEGF- C m: RNA expression and LMVD in grades 1, 2, and 3 pterygia, whereas VEGF- A m: RNA expression correlated closely with LMVD only in grade 1 pterygia. Conclusions: Lymphatic microvessel density increases dramatically in grades 2 and 3 pterygia. Transient upregulation of VEGF- C might be responsible for the occurrence of lymphangiogenesis.
Ending Page	742
Starting Page	735
Page Count	8
File Format	PDF HTM / HTML
ISSN	00039950
DOI	10.1001/archophthalmol.2012.293
Issue Number	6
Journal	Archives of Ophthalmology
Volume Number	130
Language	English
Publisher	American Medical Association
Publisher Date	2012-06-01
Access Restriction	Open
Subject Keyword	pterygium lymphatic vessels microvessels vascular endothelial growth factor c vascular endothelial growth factor a
Content Type	Text
Resource Type	Article
Subject	Ophthalmology

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