NDLI: Magnetization Transfer Ratio in Gray Matter: A Potential Surrogate Marker for Progression in Early Primary Progressive Multiple Sclerosis

Content Provider	JAMA Network
Author	Khaleeli, Zhaleh Altmann, Daniel R. Cercignani, Mara Ciccarelli, Olga Miller, David H. Thompson, Alan J.
Copyright Year	2008
Abstract	Background: Magnetization transfer imaging has the potential to provide a surrogate marker for progression in primary progressive multiple sclerosis ( PPMS). Objectives: To investigate whether brain magnetization transfer imaging, T2 lesion load, and atrophy changes over 3 years reflect concurrent clinical changes, and which baseline imaging measure best predicts progression over 3 years in early PPMS. Design: Prospective study. Setting: National Hospital for Neurology and Neurosurgery and the Institute of Neurology, London, England. Patients: Forty-seven patients with PPMS (of whom 43 completed the study) and 18 control subjects. Interventions: Brain magnetization transfer imaging (including T2-weighted images) and volume sequences every 6 months for 3 years. Main Outcome Measures: Changes in Expanded Disability Status Scale ( EDSS) score and associations with rate of change in imaging variables. Results: More rapid decline in gray matter mean and peak location magnetization transfer ratio and T2 lesion load increase were associated with greater rates of progression on the EDSS. Baseline gray matter peak height magnetization transfer ratio best predicted progression over 3 years. Conclusion: Gray matter magnetization transfer ratio meets many of the criteria for a surrogate marker of progression in early PPMS.
Ending Page	1459
Starting Page	1454
Page Count	6
File Format	PDF HTM / HTML
ISSN	00039942
DOI	10.1001/archneur.65.11.1454
Issue Number	11
Journal	Archives of Neurology
Volume Number	65
Language	English
Publisher	American Medical Association
Publisher Date	2008-11-10
Access Restriction	Open
Subject Keyword	diagnostic imaging primary progressive multiple sclerosis surrogate markers gray matter transfer technique transverse spin relaxation time magnetic resonance imaging disability atrophy brain disease progression neurosurgical procedures
Content Type	Text
Resource Type	Article
Subject	1200/1201 Neurology (clinical)

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